Steady-state pharmacokinetics of imipenem in febrile neutropenic cancer patients.

نویسندگان

  • G L Drusano
  • K I Plaisance
  • A Forrest
  • C Bustamante
  • A Devlin
  • H C Standiford
  • J C Wade
چکیده

We ascertained the pharmacokinetics of imipenem in febrile granulocytopenic cancer patients. The values observed were both different from and significantly more variable than those observed in normal volunteers. Free drug concentrations exceeded the MIC for 90% of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus strains for greater than 6 h. The MIC for 90% of Pseudomonas aeruginosa strains was exceeded for 4 h. Because imipenem induces a 2-h postantibiotic effect in P. aeruginosa, it is promising as single-agent empiric therapy in this setting.

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1. Klastersky JA. Use of imipenem as empirical treatment of febrile neutropenia. Int J Antimicrob Agents 2003; 21: 393–402. 2. Hughes WT, Armstrong D, Bodey GP et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002; 34: 730–51. 3. Mouton JW, Touzw DJ, Horrevorts AM et al. Comparative pharmacokinetics of the carbapenems: clinical impl...

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 31 9  شماره 

صفحات  -

تاریخ انتشار 1987